Lipid{polymer Hybrid Nanoparticles: Synthesis, Characterization and Applications
نویسندگان
چکیده
Nanotechnology has been extensively explored in the past decade to develop a myriad of functional nanostructures to facilitate the delivery of therapeutic and imaging agents for various medical applications. Liposomes and polymeric nanoparticles represent two primary delivery vehicles that are currently under investigation. While many advantages of these two particle platforms have been disclosed, some intrinsic limitations remain to limit their applications at certain extent. Recently, a new type of nanoparticle platform, named lipid polymer hybrid nanoparticle, has been developed that combines the positive attributes of both liposomes and polymeric nanoparticles while excluding some of their shortages. This new nanoparticle consists of a hydrophobic polymeric core, a lipid shell surrounding the polymeric core, and a hydrophilic polymer stealth layer outside the lipid shell. In this review, we ̄rst introduce the synthesis and surface functionalization techniques of the lipid polymer hybrid nanoparticle, followed by a review of typical characterization of the particles. We then summarize the current and potential medical applications of this new nanoparticle as a delivery vehicle of therapeutic and imaging agents. Finally we highlight some challenges faced in further developing this robust delivery platform.
منابع مشابه
Synthesis and Characterization of Lipid - Polymer Hybrid Nanoparticles for Combinatorial Drug
متن کامل
Preparation of polymer coated superparamagnetic Iron Oxide (Fe3O4) nanoparticles for biomedical application
Biomedical applications of superparamagnetic iron oxide nanoparticles (SPIONs) requiring precise control over their physical and magnetic properties, and proper surface treatment. Here we report a practical and effective electrochemical strategy for preparation of the polymer coated SPIONs. In this strategy, in situ polymer coating on the surface of SPIONs was achieved through electrodeposition...
متن کاملPreparation of polymer coated superparamagnetic Iron Oxide (Fe3O4) nanoparticles for biomedical application
Biomedical applications of superparamagnetic iron oxide nanoparticles (SPIONs) requiring precise control over their physical and magnetic properties, and proper surface treatment. Here we report a practical and effective electrochemical strategy for preparation of the polymer coated SPIONs. In this strategy, in situ polymer coating on the surface of SPIONs was achieved through electrodeposition...
متن کاملSynthesis and morphology characterization of SnO2 nanoparticles by hydrothermal method
Nanoparticles are widely used in different applications such as cancer cell treatment and antibacterial agents. SnO2 nanoparticles were synthesized successfully by hydrothermal method and subsequent calcination using Tin (II) chloride- dihydrate, Sodium hydroxide, in presence of Hexadecyltrimethylammoniumn bromide (CTAB) as Surfactant. These nanoparticles were characterized by using Fourier tra...
متن کاملSynthesis and morphology characterization of SnO2 nanoparticles by hydrothermal method
Nanoparticles are widely used in different applications such as cancer cell treatment and antibacterial agents. SnO2 nanoparticles were synthesized successfully by hydrothermal method and subsequent calcination using Tin (II) chloride- dihydrate, Sodium hydroxide, in presence of Hexadecyltrimethylammoniumn bromide (CTAB) as Surfactant. These nanoparticles were characterized by using Fourier tra...
متن کامل